Pub. Date : 2008 Jun
PMID : 18368030
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | While urinary L-FABP increased over 100-fold 1 day after cisplatin treatment in the transgenic mice it was significantly reduced when these transgenic mice were pretreated with bezafibrate. | Cisplatin | fatty acid binding protein 1, liver | Mus musculus |
| 2 | Immunohistochemical analysis of kidney tissue of bezafibrate-cisplatin-treated transgenic mice showed preservation of cytoplasmic L-FABP in the proximal tubule, but this was reduced in transgenic mice treated only with cisplatin. | Cisplatin | fatty acid binding protein 1, liver | Mus musculus |
| 3 | L-FABP mRNA and protein levels were significantly increased in bezafibrate-cisplatin-treated transgenic mice when compared to mice not fibrate treated. | Cisplatin | fatty acid binding protein 1, liver | Mus musculus |
| 4 | Our study shows that the bezafibrate-mediated upregulation of proximal tubule L-FABP plays a pivotal role in the reduction of cisplatin-induced acute kidney injury. | Cisplatin | fatty acid binding protein 1, liver | Mus musculus |