Title : Statins impair antitumor effects of rituximab by inducing conformational changes of CD20.

Pub. Date : 2008 Mar 25

PMID : 18366248






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Atomic force microscopy and limited proteolysis indicated that statins, through cholesterol depletion, induce conformational changes in CD20 that result in impaired binding of anti-CD20 mAb. Cholesterol keratin 20 Homo sapiens
2 Atomic force microscopy and limited proteolysis indicated that statins, through cholesterol depletion, induce conformational changes in CD20 that result in impaired binding of anti-CD20 mAb. Cholesterol keratin 20 Homo sapiens
3 An in vivo reduction of cholesterol induced by short-term treatment of five patients with hypercholesterolemia with atorvastatin resulted in reduced anti-CD20 binding to freshly isolated B cells. Cholesterol keratin 20 Homo sapiens