Title : Carbonic anhydrase-II inhibition. what are the true enzyme-inhibitory properties of the sulfamide cognate of topiramate?

Pub. Date : 2008 Apr 24

PMID : 18363349






3 Functional Relationships(s)
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1 2006, 49, 7024) proposed that an adverse steric interaction between the C8 methyl group in 2 and Ala-65 of CA-II is responsible for the diminished CA-II inhibitory potency of 2. Alanine carbonic anhydrase 2 Homo sapiens
2 2006, 49, 7024) proposed that an adverse steric interaction between the C8 methyl group in 2 and Ala-65 of CA-II is responsible for the diminished CA-II inhibitory potency of 2. Alanine carbonic anhydrase 2 Homo sapiens
3 Our results draw into question the proposed steric interaction between the C8 methyl of 2 and Ala-65 of CA-II. Alanine carbonic anhydrase 2 Homo sapiens