Pub. Date : 2008 Apr 1
PMID : 18354169
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We show that glucose uptake is limiting in T cell activation and that CD28 costimulation is required to allow maximal glucose uptake following TCR stimulation by up-regulating expression and promoting the cell surface trafficking of the glucose transporter Glut1. | Glucose | solute carrier family 2 (facilitated glucose transporter), member 1 | Mus musculus |
| 2 | We show that glucose uptake is limiting in T cell activation and that CD28 costimulation is required to allow maximal glucose uptake following TCR stimulation by up-regulating expression and promoting the cell surface trafficking of the glucose transporter Glut1. | Glucose | solute carrier family 2 (facilitated glucose transporter), member 1 | Mus musculus |
| 3 | Regulation of T cell glucose uptake and Glut1 was critical, as low glucose prevented appropriate T cell responses. | Glucose | solute carrier family 2 (facilitated glucose transporter), member 1 | Mus musculus |
| 4 | In support of this model, coexpression of Glut1 and myristoylated Akt transgenes resulted in a synergistic increase in glucose uptake and accumulation of activated T cells in vivo that were largely independent of CD28. | Glucose | solute carrier family 2 (facilitated glucose transporter), member 1 | Mus musculus |
| 5 | Induction of Glut1 protein and Akt regulation of Glut1 trafficking are therefore separable functions of CD28 costimulation that cooperate to promote glucose metabolism for T cell activation and proliferation. | Glucose | solute carrier family 2 (facilitated glucose transporter), member 1 | Mus musculus |
| 6 | Induction of Glut1 protein and Akt regulation of Glut1 trafficking are therefore separable functions of CD28 costimulation that cooperate to promote glucose metabolism for T cell activation and proliferation. | Glucose | solute carrier family 2 (facilitated glucose transporter), member 1 | Mus musculus |