Title : Structural elements regulating amyloidogenesis: a cholinesterase model system.

Pub. Date : 2008 Mar 19

PMID : 18350169






1 Functional Relationships(s)
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1 Consistently with the experimental observations and assembly models for other amyloid systems, we propose a model for AChE(586-599) assembly in which a steric-zipper formed through specific interactions (hydrophobic, electrostatic, cation-pi, SH-aromatic, metal chelation and polar-polar) would maintain the beta-sheets together. Metals acetylcholinesterase (Cartwright blood group) Homo sapiens