Pub. Date : 2009 Feb
PMID : 18331557
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Expression of phosphorylated Akt in oral carcinogenesis and its induction by nicotine and alkaline stimulation. | Nicotine | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | Western blotting was used to detect time-dependent induction of p-Akt by 100 microM nicotine in normal human bronchial epithelial cell (NHBE), normal human oral keratinocytes (NHOK), immortalized human epithelial cells (HaCaT) and OEC-M1 cells, dose-dependent induction of p-Akt in OEC-M1 and HaCaT cells and pH effect of p-Akt in OEC-M1. | Nicotine | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | Western blotting was used to detect time-dependent induction of p-Akt by 100 microM nicotine in normal human bronchial epithelial cell (NHBE), normal human oral keratinocytes (NHOK), immortalized human epithelial cells (HaCaT) and OEC-M1 cells, dose-dependent induction of p-Akt in OEC-M1 and HaCaT cells and pH effect of p-Akt in OEC-M1. | Nicotine | AKT serine/threonine kinase 1 | Homo sapiens |
| 4 | Western blotting was used to detect time-dependent induction of p-Akt by 100 microM nicotine in normal human bronchial epithelial cell (NHBE), normal human oral keratinocytes (NHOK), immortalized human epithelial cells (HaCaT) and OEC-M1 cells, dose-dependent induction of p-Akt in OEC-M1 and HaCaT cells and pH effect of p-Akt in OEC-M1. | Nicotine | AKT serine/threonine kinase 1 | Homo sapiens |
| 5 | A time-dependent increase in p-Akt in the NHBE, NHOK, HaCaT and OEC-M1 cell lines was observed with 100 microM nicotine treatment. | Nicotine | AKT serine/threonine kinase 1 | Homo sapiens |
| 6 | The dose-dependent increase in p-Akt by nicotine treatment in HaCaT and OEC-M1 cells was obviously observed. | Nicotine | AKT serine/threonine kinase 1 | Homo sapiens |
| 7 | CONCLUSION: A potential role for increased p-Akt may relate to the dose and time of nicotine use. | Nicotine | AKT serine/threonine kinase 1 | Homo sapiens |