Pub. Date : 2008 Jul 1
PMID : 18328637
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Protective effect against alcohol dependence of the thermolabile variant of MTHFR. | Alcohols | methylenetetrahydrofolate reductase | Homo sapiens |
| 2 | Our objective was to study the prevalence of the MTHFR C677T polymorphism in alcohol-dependent subjects and the influence of this polymorphism on symptoms associated with alcoholism. | Alcohols | methylenetetrahydrofolate reductase | Homo sapiens |
| 3 | METHODS: MTHFR C677T polymorphism was determined in 93 control subjects and 242 alcohol-dependent subjects. | Alcohols | methylenetetrahydrofolate reductase | Homo sapiens |
| 4 | Alcohol-dependent subjects showed a significant decrease in MTHFR 677TT prevalence (9%, 21/242) compared to controls (18%, 17/93) (p<0.02). | Alcohols | methylenetetrahydrofolate reductase | Homo sapiens |
| 5 | CONCLUSION: MTHFR 677TT genotype could play a protective role against alcohol dependence. | Alcohols | methylenetetrahydrofolate reductase | Homo sapiens |
| 6 | Moreover, when subjects with MTHFR 677TT genotype become dependent to alcohol, they seem to constitute a subgroup of alcoholic patients with a decreased risk for developing neurotoxic withdrawal symptoms and hepatic toxicity. | Alcohols | methylenetetrahydrofolate reductase | Homo sapiens |