Title : Delivery of biologically active anti-inflammatory cytokines IL-10 and IL-1ra in vivo by the Shigella type III secretion apparatus.

Pub. Date : 2008 Mar 15

PMID : 18322242






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 YopE(50)-IL-10, IpaH(60)-IL-10, and IpaH(60)-IL-1ra were efficiently secreted via the T3S apparatus of Shigella. ipah interleukin 1 receptor antagonist Mus musculus
2 In a murine model, Shigella strains expressing YopE(50)-IL-10, IpaH(60)-IL-10, and IpaH(60)-IL-1ra induced a lower mortality in mice that was associated with reduced inflammation and a restricted localization of bacteria within the lung tissues as compared with wild-type Shigella. ipah interleukin 1 receptor antagonist Mus musculus