Title : Metformin treatment for four years to reduce total and visceral fat in low birth weight girls with precocious pubarche.

Pub. Date : 2008 May

PMID : 18319306






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1 RESULTS: Metformin-treated girls gained on average 5.5 kg (or approximately 50%) less fat, after 4 yr were less insulin resistant and less hyperandrogenic, had lower IGF-I levels and a less atherogenic lipid profile, and were less likely to be post-menarcheal than untreated girls, whereas their gain in height, lean mass, and bone mineral density were similar. Metformin insulin like growth factor 1 Homo sapiens