Title : 7beta-Hydroxycholesterol and 25-hydroxycholesterol-induced interleukin-8 secretion involves a calcium-dependent activation of c-fos via the ERK1/2 signaling pathway in THP-1 cells: oxysterols-induced IL-8 secretion is calcium-dependent.

Pub. Date : 2009 Apr

PMID : 18317936






2 Functional Relationships(s)
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1 These results demonstrate that oxysterol-induced IL-8 secretion is a calcium-dependent phenomenon involving the MEK/ERK1/2 pathway leading to the activation of IL-8 gene via AP-1 (c-fos). Oxysterols Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens
2 These results demonstrate that oxysterol-induced IL-8 secretion is a calcium-dependent phenomenon involving the MEK/ERK1/2 pathway leading to the activation of IL-8 gene via AP-1 (c-fos). Oxysterols Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens