Title : Thrombostatin FM compounds: direct thrombin inhibitors - mechanism of action in vitro and in vivo.

Pub. Date : 2008 May

PMID : 18315550






1 Functional Relationships(s)
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1 The crystal structure of thrombin in complex with FM19 shows that the N-terminal D-Arg retrobinds into the S1 pocket, its second residue Oic interacts with His-57, Tyr-60a and Trp-60d, and its C-terminal p-methyl Phe engages thrombin"s aryl binding site composed of Ile-174, Trp-215, and Leu-99. Tyrosine coagulation factor II Mus musculus