Title : Compartmentation of intracellular folates. Failure to interconvert tetrahydrofolate cofactors to dihydrofolate in mitochondria of L1210 leukemia cells treated with trimetrexate.

Pub. Date : 1991 Aug 8

PMID : 1831361






1 Functional Relationships(s)
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1 The present paper evaluates the possibility that tetrahydrofolate cofactors in subcellular organelles, in particular, mitochondria, are unavailable for oxidation by thymidylate synthase. 5,6,7,8-tetrahydrofolic acid thymidylate synthase Mus musculus