Title : Sorafenib, but not sunitinib, affects function of dendritic cells and induction of primary immune responses.

Pub. Date : 2008 Jun 15

PMID : 18310500






1 Functional Relationships(s)
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1 Sorafenib, but not sunitinib, inhibits function of DCs, characterized by reduced secretion of cytokines and expression of CD1a, major histocompatibility complex, and costimulatory molecules in response to TLR ligands as well as by their impaired ability to migrate and stimulate T-cell responses. Sorafenib CD1a molecule Homo sapiens