Title : Impact of genetic polymorphisms in CYP2C8 and rosiglitazone intake on the urinary excretion of dihydroxyeicosatrienoic acids.

Pub. Date : 2008 Mar

PMID : 18303964






1 Functional Relationships(s)
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1 UNLABELLED: The cytochrome P450 enzymes CYP2C8, CYP2C9 and CYP2J2 generate 8,9-, 11,12-, and 14,15-epoxyeicosatrienic acid (EET) from arachidonic acid, and these EETs are then hydrolyzed to dihydroxyeicosatrienoic acids (DHET) before excretion into the urine. dihydroxyeicosatrienoic acids cytochrome P450 family 2 subfamily J member 2 Homo sapiens