Title : Efungumab and caspofungin: pre-clinical data supporting synergy.

Pub. Date : 2008 May

PMID : 18299636






1 Functional Relationships(s)
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1 RESULTS: The FICIs of efungumab and caspofungin at MIC-0 and MIC-2, respectively, were: fluconazole-susceptible Candida albicans: 0.5, 0.52; fluconazole-resistant C. albicans, Candida tropicalis and Candida krusei: 0.5, 0.5; Candida parapsilosis: 2, 0.5; Candida glabrata: 0.26, 0.28; and Candida guilliermondii: 2, 0.27. Caspofungin inositolphosphotransferase Saccharomyces cerevisiae S288C