Title : Different effects of all-trans-retinoic acid on phorbol ester-stimulated and phytohemagglutinin-stimulated interleukin-2 expression in human T-cell lymphoma HUT-78 cells.

Pub. Date : 2008

PMID : 18296860






3 Functional Relationships(s)
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1 ATRA enhanced the production of IL-2 stimulated by TPA, but suppressed that stimulated by PHA. Tetradecanoylphorbol Acetate interleukin 2 Homo sapiens
2 Since PKC- beta1 has been suggested to be important for the secretion and gene expression of IL-2 and since the activator protein-l binding site is present in the promoter of the IL-2 gene, these findings may explain the differences in ATRA"s effects on TPA- and PHA-stimulated IL-2 expression. Tetradecanoylphorbol Acetate interleukin 2 Homo sapiens
3 Since PKC- beta1 has been suggested to be important for the secretion and gene expression of IL-2 and since the activator protein-l binding site is present in the promoter of the IL-2 gene, these findings may explain the differences in ATRA"s effects on TPA- and PHA-stimulated IL-2 expression. Tetradecanoylphorbol Acetate interleukin 2 Homo sapiens