Pub. Date : 2008 Mar
PMID : 18292946
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Dexamethasone interferes with trastuzumab-induced cell growth inhibition through restoration of AKT activity in BT-474 breast cancer cells. | Dexamethasone | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | Dex restored the trastuzumab-induced suppression of AKT without affecting ERK activity. | Dexamethasone | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | It was concluded that Dex interferes with trastuzumab-induced cell growth inhibition, at least partially, through the restoration of trastuzumab-induced AKT suppression and subsequent pRB dephosphorylation in BT-474 breast cancer cells. | Dexamethasone | AKT serine/threonine kinase 1 | Homo sapiens |