Title : Knockdown of Mgat5 inhibits breast cancer cell growth with activation of CD4+ T cells and macrophages.

Pub. Date : 2008 Mar 1

PMID : 18292539






2 Functional Relationships(s)
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1 Importantly, reduction of complex N-glycans on MA782 tumor cells by Mgat5-shRNA resulted in significantly increased proliferation and CD45 surface expression of CD4+ T cells. n-glycans mannoside acetylglucosaminyltransferase 5 Mus musculus
2 Our data suggest Mgat5-shRNA could serve as a useful tool to treat breast cancer as well as a powerful tool for the functional investigation of N-glycans and glycoprotein synthesis. n-glycans mannoside acetylglucosaminyltransferase 5 Mus musculus