Pub. Date : 2008 Mar 15
PMID : 18289803
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Interleukin-8 induction by the environmental contaminant benzo(a)pyrene is aryl hydrocarbon receptor-dependent and leads to lung inflammation. | Benzo(a)pyrene | C-X-C motif chemokine ligand 8 | Homo sapiens |
| 2 | In primary human macrophages, BP was shown to induce IL-8 expression at both mRNA and secretion levels in a dose-dependent manner. | Benzo(a)pyrene | C-X-C motif chemokine ligand 8 | Homo sapiens |
| 3 | Such an up-regulation was likely linked to aryl hydrocarbon receptor (AhR)-activation since BP-mediated IL-8 induction was reduced after AhR expression knock-down through RNA interference. | Benzo(a)pyrene | C-X-C motif chemokine ligand 8 | Homo sapiens |
| 4 | Moreover, electrophoretic mobility shift assays (EMSAs) and chromatin immunoprecipitation experiments showed BP-triggered binding of AhR to a consensus xenobiotic responsive element (XRE) found in the human IL-8 promoter. | Benzo(a)pyrene | C-X-C motif chemokine ligand 8 | Homo sapiens |
| 5 | Overall, these data highlight an AhR-dependent regulation of IL-8 in response to BP that likely contributes to the airway inflammatory effects of this environmental chemical. | Benzo(a)pyrene | C-X-C motif chemokine ligand 8 | Homo sapiens |