Title : [Prediction of response to docetaxel in breast cancer].

Pub. Date : 2008 Feb

PMID : 18281755






1 Functional Relationships(s)
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1 Recent studies in this area have demonstrated various mechanisms involved in the anti-tumor activity of docetaxel: (1) efflux (p-glycoprotein), (2) metabolism (CYP3A4), (3) beta-tubulin (isotype class I and III), (4) cell cycle (HER2, BRCA1), (5) apoptosis (p53, Bcl-2, thioredoxin), and (6) cell proliferation (MIB-1, nuclear grade). Docetaxel BRCA1 DNA repair associated Homo sapiens