Pub. Date : 2008 Apr 15
PMID : 18281504
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Vascular dermatan sulfate regulates the antithrombotic activity of heparin cofactor II. | Dermatan Sulfate | serine (or cysteine) peptidase inhibitor, clade D, member 1 | Mus musculus |
| 2 | Dermatan sulfate (DS) and heparan sulfate (HS) increase the rate of inhibition of thrombin by HCII in vitro, but it is unknown whether vascular glycosaminoglycans play a role in the antithrombotic effect of HCII in vivo. | Dermatan Sulfate | serine (or cysteine) peptidase inhibitor, clade D, member 1 | Mus musculus |
| 3 | Dermatan sulfate (DS) and heparan sulfate (HS) increase the rate of inhibition of thrombin by HCII in vitro, but it is unknown whether vascular glycosaminoglycans play a role in the antithrombotic effect of HCII in vivo. | Dermatan Sulfate | serine (or cysteine) peptidase inhibitor, clade D, member 1 | Mus musculus |
| 4 | Dermatan sulfate (DS) and heparan sulfate (HS) increase the rate of inhibition of thrombin by HCII in vitro, but it is unknown whether vascular glycosaminoglycans play a role in the antithrombotic effect of HCII in vivo. | Dermatan Sulfate | serine (or cysteine) peptidase inhibitor, clade D, member 1 | Mus musculus |
| 5 | When HCII was incubated with frozen sections of the mouse carotid artery, it bound specifically to DS in the adventitia. | Dermatan Sulfate | serine (or cysteine) peptidase inhibitor, clade D, member 1 | Mus musculus |
| 6 | These results support the hypothesis that HCII interacts with DS in the vessel wall after disruption of the endothelium and that this interaction regulates thrombus formation in vivo. | Dermatan Sulfate | serine (or cysteine) peptidase inhibitor, clade D, member 1 | Mus musculus |