Title : Mgmt deficiency alters the in vivo mutational spectrum of tissues exposed to the tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK).

Pub. Date : 2008 Apr

PMID : 18281247






1 Functional Relationships(s)
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1 In keeping with the high levels of MGMT expressed in the liver, more pronounced mutagenic effects and greater differences in O(6) position of deoxyguanosine adduct levels following NNK were observed in Mgmt(-/-) versus wild-type mice. Deoxyguanosine O-6-methylguanine-DNA methyltransferase Mus musculus