Pub. Date : 2008 Sep
PMID : 18281123
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | A combination of sulindac and arsenic trioxide synergistically induces apoptosis in human lung cancer H1299 cells via c-Jun NH2-terminal kinase-dependent Bcl-xL phosphorylation. | Arsenic Trioxide | BCL2 like 1 | Homo sapiens |
| 2 | Interestingly, a slower migrating Bcl-xL band was observed on immunoblots after treatment of cells with sulindac/ATO. | Arsenic Trioxide | BCL2 like 1 | Homo sapiens |
| 3 | Treatment with SP600125 and transfection with DN-JNK blocked Bcl-xL phosphorylation, suggesting that JNK plays an important role in sulindac/ATO-induced Bcl-xL phosphorylation. | Arsenic Trioxide | BCL2 like 1 | Homo sapiens |
| 4 | Treatment with SP600125 and transfection with DN-JNK blocked Bcl-xL phosphorylation, suggesting that JNK plays an important role in sulindac/ATO-induced Bcl-xL phosphorylation. | Arsenic Trioxide | BCL2 like 1 | Homo sapiens |
| 5 | In conclusion, in H1299 human NSCLC cells, sulindac and ATO synergistically induce a high degree of apoptosis, which is mediated by the ROS-dependent JNK activation pathway via Bcl-xL phosphorylation. | Arsenic Trioxide | BCL2 like 1 | Homo sapiens |