Pub. Date : 2008 May 1
PMID : 18281070
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In utero exposure to benzene increases embryonic c-Myb and Pim-1 protein levels in CD-1 mice. | Benzene | proviral integration site 1 | Mus musculus |
| 2 | We hypothesize that in utero exposure to benzene may cause leukemogenesis by affecting the embryonic c-Myb/Pim-1 signaling pathway and that this is mediated by oxidative stress. | Benzene | proviral integration site 1 | Mus musculus |
| 3 | Our results show increased oxidative stress at 4 and 24 h after exposure, increased phosphorylated Pim-1 protein levels 4 h after benzene exposure, and increased Pim-1 levels at 24 and 48 h after benzene exposure. | Benzene | proviral integration site 1 | Mus musculus |
| 4 | Our results show increased oxidative stress at 4 and 24 h after exposure, increased phosphorylated Pim-1 protein levels 4 h after benzene exposure, and increased Pim-1 levels at 24 and 48 h after benzene exposure. | Benzene | proviral integration site 1 | Mus musculus |
| 5 | PEG-catalase pretreatment prevented benzene-mediated increases in embryonic c-Myb and Pim-1 protein levels, and benzene-induced oxidative stress. | Benzene | proviral integration site 1 | Mus musculus |
| 6 | These results support a role for ROS in c-Myb and Pim-1 alterations after in utero benzene exposure. | Benzene | proviral integration site 1 | Mus musculus |