Title : Lysophosphatidylcholine induces neuropathic pain through an action of autotaxin to generate lysophosphatidic acid.

Pub. Date : 2008 Mar 18

PMID : 18280050






3 Functional Relationships(s)
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1 Recently, we reported that lysophosphatidic acid (LPA) induces neuropathic pain as well as demyelination and pain-related protein expression changes via LPA(1) receptor signaling. lysophosphatidic acid lysophosphatidic acid receptor 1 Mus musculus
2 Recently, we reported that lysophosphatidic acid (LPA) induces neuropathic pain as well as demyelination and pain-related protein expression changes via LPA(1) receptor signaling. lysophosphatidic acid lysophosphatidic acid receptor 1 Mus musculus
3 These findings suggest that intrathecally-injected LPC is converted to LPA by ATX, and this LPA activates the LPA(1) receptor to initiate neuropathic pain. lysophosphatidic acid lysophosphatidic acid receptor 1 Mus musculus