Title : The p38 mitogen-activated protein kinase pathway plays a critical role in PAR2-induced endothelial IL-8 production and leukocyte adhesion.

Pub. Date : 2008 Nov

PMID : 18277946






1 Functional Relationships(s)
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1 Both PAR2-AP and the endogenous PAR2 activator trypsin caused concentration- and time-dependent increase in endothelial IL-8 production, and this effect was concentration dependently and selectively attenuated by the p38 mitogen-activated protein kinase (MAPK) inhibitor SB203580. SB 203580 C-X-C motif chemokine ligand 8 Homo sapiens