Title : Impact of basolateral multidrug resistance-associated protein (Mrp) 3 and Mrp4 on the hepatobiliary disposition of fexofenadine in perfused mouse livers.

Pub. Date : 2008 May

PMID : 18276836






4 Functional Relationships(s)
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1 Recently, we showed that in mice fexofenadine is excreted into bile primarily by multidrug resistance-associated protein (Mrp) 2 (Abcc2). fexofenadine ATP-binding cassette, sub-family C (CFTR/MRP), member 2 Mus musculus
2 Recently, we showed that in mice fexofenadine is excreted into bile primarily by multidrug resistance-associated protein (Mrp) 2 (Abcc2). fexofenadine ATP-binding cassette, sub-family C (CFTR/MRP), member 2 Mus musculus
3 As expected, in Abcc2(-/-) mice, fexofenadine was redirected from the canalicular to the basolateral membrane for excretion. fexofenadine ATP-binding cassette, sub-family C (CFTR/MRP), member 2 Mus musculus
4 In Abcc2(-/-)/Abcc3(-/-) double-knockout mice, fexofenadine biliary excretion was impaired, but perfusate recovery was similar to that in wild-type mice and more than 2-fold higher than that in Abcc3(-/-) mice, presumably due to compensatory basolateral transport mechanism(s). fexofenadine ATP-binding cassette, sub-family C (CFTR/MRP), member 2 Mus musculus