Pub. Date : 2008 May
PMID : 18276836
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Impact of basolateral multidrug resistance-associated protein (Mrp) 3 and Mrp4 on the hepatobiliary disposition of fexofenadine in perfused mouse livers. | fexofenadine | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | Mus musculus |
| 2 | In the present study, the roles of Mrp3 (Abcc3) and Mrp4 (Abcc4) in the hepatobiliary disposition of fexofenadine were examined in knockout mice using in situ liver perfusion. | fexofenadine | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | Mus musculus |
| 3 | Compared with that in wild-type mice, basolateral excretion of fexofenadine was impaired, resulting in a approximately 50% decrease in perfusate recovery in Abcc3(-/-) mice; in contrast, fexofenadine hepatobiliary disposition was unaltered in Abcc4(-/-) mice. | fexofenadine | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | Mus musculus |