Title : Generation of mice transgenic for human CYP2C18 and CYP2C19: characterization of the sexually dimorphic gene and enzyme expression.

Pub. Date : 2008 May

PMID : 18276835






1 Functional Relationships(s)
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1 Immunoblotting using an antipeptide antiserum, reactive with human CYP2Cs and mouse CYP2C70, revealed increased immunoreactive protein in liver microsomes from heterozygous transgenic male mice and a concomitant increase in 5"-hydroxylation of R-omeprazole and S-mephenytoin intrinsic clearance, consistent with CYP2C19 overexpression. Mephenytoin cytochrome P450, family 2, subfamily c, polypeptide 70 Mus musculus