Title : PTEN deletion leads to deregulation of antioxidants and increased oxidative damage in mouse embryonic fibroblasts.

Pub. Date : 2008 Apr 15

PMID : 18275859






1 Functional Relationships(s)
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1 In these Pten-deleted MEFs, the basal levels of reactive oxygen species (ROS) were increased, and both the basal level and the ROS-induced oxidative damage of DNA were increased, as evidenced by increased levels of hydrogen peroxide (H2O2), superoxide anion, 8-hydroxy-2"-deoxyguanosine, and DNA double-strand breaks. Superoxides phosphatase and tensin homolog Mus musculus