Title : Therapeutic metformin/AMPK activation promotes the angiogenic phenotype in the ERalpha negative MDA-MB-435 breast cancer model.

Pub. Date : 2009 Jan

PMID : 18256928






3 Functional Relationships(s)
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1 However, when ERalpha negative MDA-MB-435 cells were treated with metformin, they demonstrated increased expression of vascular endothelial growth factor (VEGF) in an AMPK dependent manner; while the ERalpha positive MCF-7 cells did not. Metformin vascular endothelial growth factor A Homo sapiens
2 However, when ERalpha negative MDA-MB-435 cells were treated with metformin, they demonstrated increased expression of vascular endothelial growth factor (VEGF) in an AMPK dependent manner; while the ERalpha positive MCF-7 cells did not. Metformin vascular endothelial growth factor A Homo sapiens
3 The metformin-treated group showed increased VEGF expression, intratumoral microvascular density and reduced necrosis. Metformin vascular endothelial growth factor A Homo sapiens