Title : Cisplatin regulates Sertoli cell expression of transferrin and interleukins.

Pub. Date : 2008 Feb 13

PMID : 18248879






4 Functional Relationships(s)
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1 In addition, CDDP significantly increased the level of COX-2, PGs, and ILs in the late phase (within 24h). Cisplatin cytochrome c oxidase II, mitochondrial Rattus norvegicus
2 When ERK activity inhibitor (PD98059, 10 microM) or COX-2 activity inhibitor (NS-398, 10 microM) was used, CDDP reduction of TF and induction of PG and IL expression were prevented, suggesting that the detrimental effects on spermatogenesis through the impairment of SC induced by CDDP are mediated by the activation of ERK1/2 and COX-2 pathways in SC. Cisplatin cytochrome c oxidase II, mitochondrial Rattus norvegicus
3 When ERK activity inhibitor (PD98059, 10 microM) or COX-2 activity inhibitor (NS-398, 10 microM) was used, CDDP reduction of TF and induction of PG and IL expression were prevented, suggesting that the detrimental effects on spermatogenesis through the impairment of SC induced by CDDP are mediated by the activation of ERK1/2 and COX-2 pathways in SC. Cisplatin cytochrome c oxidase II, mitochondrial Rattus norvegicus
4 When ERK activity inhibitor (PD98059, 10 microM) or COX-2 activity inhibitor (NS-398, 10 microM) was used, CDDP reduction of TF and induction of PG and IL expression were prevented, suggesting that the detrimental effects on spermatogenesis through the impairment of SC induced by CDDP are mediated by the activation of ERK1/2 and COX-2 pathways in SC. Cisplatin cytochrome c oxidase II, mitochondrial Rattus norvegicus