Pub. Date : 2008 Feb 13
PMID : 18248879
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In addition, CDDP significantly increased the level of COX-2, PGs, and ILs in the late phase (within 24h). | Cisplatin | cytochrome c oxidase II, mitochondrial | Rattus norvegicus |
| 2 | When ERK activity inhibitor (PD98059, 10 microM) or COX-2 activity inhibitor (NS-398, 10 microM) was used, CDDP reduction of TF and induction of PG and IL expression were prevented, suggesting that the detrimental effects on spermatogenesis through the impairment of SC induced by CDDP are mediated by the activation of ERK1/2 and COX-2 pathways in SC. | Cisplatin | cytochrome c oxidase II, mitochondrial | Rattus norvegicus |
| 3 | When ERK activity inhibitor (PD98059, 10 microM) or COX-2 activity inhibitor (NS-398, 10 microM) was used, CDDP reduction of TF and induction of PG and IL expression were prevented, suggesting that the detrimental effects on spermatogenesis through the impairment of SC induced by CDDP are mediated by the activation of ERK1/2 and COX-2 pathways in SC. | Cisplatin | cytochrome c oxidase II, mitochondrial | Rattus norvegicus |
| 4 | When ERK activity inhibitor (PD98059, 10 microM) or COX-2 activity inhibitor (NS-398, 10 microM) was used, CDDP reduction of TF and induction of PG and IL expression were prevented, suggesting that the detrimental effects on spermatogenesis through the impairment of SC induced by CDDP are mediated by the activation of ERK1/2 and COX-2 pathways in SC. | Cisplatin | cytochrome c oxidase II, mitochondrial | Rattus norvegicus |