Title : Iron depletion by deferoxamine up-regulates glucose uptake and insulin signaling in hepatoma cells and in rat liver.

Pub. Date : 2008 Mar

PMID : 18245813






1 Functional Relationships(s)
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1 Deferoxamine consistently increased the phosphorylation status of Akt/PKB and its targets FoxO1 and Gsk3beta, which mediate the effect of insulin on gluconeogenesis and glycogen synthesis, and up-regulated genes involved in glucose uptake and utilization. Deferoxamine forkhead box O1 Rattus norvegicus