Title : Different effects of enoxaparin and unfractionated heparin on some thrombogenesis markers during hemodialysis: a cross-over study.

Pub. Date : 2009 Feb

PMID : 18234290






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1 We aimed to investigate the effect of UFH and enoxaparin on plasma levels of prothrombin fragment 1+2 (PF 1+2) and thrombin/antithrombin complex (TAT) as markers of intravascular thrombogenesis during HD. Enoxaparin PHD finger protein 12 Homo sapiens
2 PF 1+2 significantly decreased during both UFH (chi(2) ANOVA=9.82, P=0.007) and enoxaparin (chi(2) ANOVA=29.40, P<10(-6)) anticoagulated HD, while over-HD TAT levels changes differed depending on the type of heparin. Enoxaparin PHD finger protein 12 Homo sapiens
3 The switch from enoxaparin to UFH treatment was connected with a significantly higher PF 1+2 after 10 and 180 min as well as higher TAT concentration after 180 min of HD. Enoxaparin PHD finger protein 12 Homo sapiens
4 Only during enoxaparin anticoagulated HD 34% PF 1+2 decrease and TAT levels after 180 min of HD was closely associated with heparin dosage. Enoxaparin PHD finger protein 12 Homo sapiens