Title : Structural basis of interactions between human glutamate carboxypeptidase II and its substrate analogs.

Pub. Date : 2008 Mar 7

PMID : 18234225






2 Functional Relationships(s)
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1 In this article, we have extended structural characterization of GCPII to its S1 site by using dipeptide-based inhibitors that interact with both S1 and S1" sites of the enzyme. Dipeptides folate hydrolase 1 Homo sapiens
2 Direct interactions between the positively charged guanidinium groups of Arg534 and Arg536 and a P1 moiety of a substrate/inhibitor provide mechanistic explanation of GCPII preference for acidic dipeptides. Dipeptides folate hydrolase 1 Homo sapiens