Title : Functional involvement of the organic cation transporter 2 (rOct2) in the renal uptake of organic cations in rats.

Pub. Date : 2008 Jan-Feb

PMID : 18230276






2 Functional Relationships(s)
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1 This study examined the contribution made by organic cation transporters (hOCT/rOct) to the saturable component of the renal uptake of 1-methyl-4-phenylpyridinium, tetraethylammonium (TEA), cimetidine and metformin into rOct2-expressing HEK293 cells and rat kidney slices. Tetraethylammonium solute carrier family 22 member 2 Rattus norvegicus
2 This suggests that the saturable components involved in the renal uptake of TEA, cimetidine and metformin are mediated mainly by rOct2. Tetraethylammonium solute carrier family 22 member 2 Rattus norvegicus