Pub. Date : 2008 Mar
PMID : 18215451
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Different modes of inhibition of mouse Cyp2a5 and rat CYP2A3 by the food-derived 8-methoxypsoralen. | Methoxsalen | cytochrome P450, family 2, subfamily a, polypeptide 3 | Rattus norvegicus |
| 2 | There is no published data on the inhibition of CYP2A3 by 8-MOP. | Methoxsalen | cytochrome P450, family 2, subfamily a, polypeptide 3 | Rattus norvegicus |
| 3 | By contrast, 8-MOP was able to inhibit CYP2A3-mediated coumarin 7-hydroxylase only in a non-competitive way (K(iu)=0.22 microM). | Methoxsalen | cytochrome P450, family 2, subfamily a, polypeptide 3 | Rattus norvegicus |
| 4 | By contrast, 8-MOP was able to inhibit CYP2A3-mediated coumarin 7-hydroxylase only in a non-competitive way (K(iu)=0.22 microM). | Methoxsalen | cytochrome P450, family 2, subfamily a, polypeptide 3 | Rattus norvegicus |
| 5 | In conclusion, we showed that 8-MOP inhibits Cyp2a5 and CYP2A3 through different mechanisms. | Methoxsalen | cytochrome P450, family 2, subfamily a, polypeptide 3 | Rattus norvegicus |