Title : L-Xylulose reductase is involved in 9,10-phenanthrenequinone-induced apoptosis in human T lymphoma cells.

Pub. Date : 2008 Mar 15

PMID : 18206670






4 Functional Relationships(s)
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1 L-Xylulose reductase is involved in 9,10-phenanthrenequinone-induced apoptosis in human T lymphoma cells. 9,10-phenanthrenequinone dicarbonyl and L-xylulose reductase Homo sapiens
2 Surprisingly, the ROS generation and cytotoxicity by 9,10-PQ were augmented in an XR-transformed cell line. 9,10-phenanthrenequinone dicarbonyl and L-xylulose reductase Homo sapiens
3 XR indeed reduced 9,10-PQ and produced superoxide anion through redox cycling. 9,10-phenanthrenequinone dicarbonyl and L-xylulose reductase Homo sapiens
4 Moreover, the 9,10-PQ-induced apoptosis was partially inhibited by the pretreatment with XR-specific inhibitors. 9,10-phenanthrenequinone dicarbonyl and L-xylulose reductase Homo sapiens