Pub. Date : 2008 Jan 16
PMID : 18197247
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Adr1 and Cat8 mediate coactivator recruitment and chromatin remodeling at glucose-regulated genes. | Glucose | DNA-binding transcription factor ADR1 | Saccharomyces cerevisiae S288C |
| 2 | BACKGROUND: Adr1 and Cat8 co-regulate numerous glucose-repressed genes in S. cerevisiae, presenting a unique opportunity to explore their individual roles in coactivator recruitment, chromatin remodeling, and transcription. | Glucose | DNA-binding transcription factor ADR1 | Saccharomyces cerevisiae S288C |
| 3 | METHODOLOGY/PRINCIPAL FINDINGS: We determined the individual contributions of Cat8 and Adr1 on the expression of a cohort of glucose-repressed genes and found three broad categories: genes that need both activators for full derepression, genes that rely mostly on Cat8 and genes that require only Adr1. | Glucose | DNA-binding transcription factor ADR1 | Saccharomyces cerevisiae S288C |
| 4 | METHODOLOGY/PRINCIPAL FINDINGS: We determined the individual contributions of Cat8 and Adr1 on the expression of a cohort of glucose-repressed genes and found three broad categories: genes that need both activators for full derepression, genes that rely mostly on Cat8 and genes that require only Adr1. | Glucose | DNA-binding transcription factor ADR1 | Saccharomyces cerevisiae S288C |
| 5 | CONCLUSIONS/SIGNIFICANCE: Thus, at many of the glucose-repressed genes, Cat8 and Adr1 appear to have interchangeable roles and promoter architecture may dictate the roles of these activators. | Glucose | DNA-binding transcription factor ADR1 | Saccharomyces cerevisiae S288C |