Pub. Date : 2008 Jun 1
PMID : 18189268
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Additionally, we found that sub-lethal doses of sanguinarine remarkably sensitized breast cancer cells to TRAIL-mediated apoptosis, but the cell death induced by sanguinarine and TRAIL in combination was not blocked by overexpression of Bcl-2 or Akt. | sanguinarine | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | Additionally, we found that sub-lethal doses of sanguinarine remarkably sensitized breast cancer cells to TRAIL-mediated apoptosis, but the cell death induced by sanguinarine and TRAIL in combination was not blocked by overexpression of Bcl-2 or Akt. | sanguinarine | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | Therefore, combinatory treatment of sanguinarine and TRAIL may overcome the resistance of breast cancer cells due to overexpression of Akt or Bcl-2. | sanguinarine | AKT serine/threonine kinase 1 | Homo sapiens |