Pub. Date : 2008 Mar 21
PMID : 18180294
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The result of extreme unconjugated bilirubin in Ugt1(-/-) mice, comparable to the induced levels noted in patients with Crigler-Najjar type 1 disease, is fatal in neonatal Ugt1(-/-) mice within 2 weeks following birth. | Bilirubin | UDP glucuronosyltransferase 1 family, polypeptide A2 | Mus musculus |
| 2 | Thus, the loss of UGT1A function in Ugt1(-/-) mice leads to a metabolic syndrome that can serve as a model to further investigate the toxicities associated with unconjugated bilirubin and the impact of this disease in humans. | Bilirubin | UDP glucuronosyltransferase 1 family, polypeptide A2 | Mus musculus |