Title : The effect of the proteasome inhibitor bortezomib on acute myeloid leukemia cells and drug resistance associated with the CD34+ immature phenotype.

Pub. Date : 2008 Jan

PMID : 18166786






4 Functional Relationships(s)
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1 DESIGN AND METHODS: We studied the in vitro activity and mechanism of action of bortezomib on both cell lines and fresh cells from 28 AML patients including CD34(+) and CD34(-) cases. Bortezomib CD34 molecule Homo sapiens
2 DESIGN AND METHODS: We studied the in vitro activity and mechanism of action of bortezomib on both cell lines and fresh cells from 28 AML patients including CD34(+) and CD34(-) cases. Bortezomib CD34 molecule Homo sapiens
3 The apoptotic activity of bortezomib on fresh CD34(+) blast cells from patients was similar to that observed on CD34(-)blast cells. Bortezomib CD34 molecule Homo sapiens
4 Importantly, bortezomib was significantly more active than doxorubicin in the immature CD34(+) cells, while there were no differences in its action on CD34(-) cells. Bortezomib CD34 molecule Homo sapiens