Pub. Date : 2008 Jan 23
PMID : 18166059
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Balancing conformational and oxidative kinetic traps during the folding of bovine pancreatic trypsin inhibitor (BPTI) with glutathione and glutathione disulfide. | Glutathione Disulfide | spleen trypsin inhibitor I | Bos taurus |
| 2 | Under traditional conditions, 0.125 mM glutathione disulfide (GSSG) and no glutathione (GSH), the folding pathway of BPTI proceeds through a nonproductive route via N* (a two disulfide intermediate), or a productive route via N" (and other two disulfide intermediates which are in rapid equilibrium with N"). | Glutathione Disulfide | spleen trypsin inhibitor I | Bos taurus |
| 3 | Under traditional conditions, 0.125 mM glutathione disulfide (GSSG) and no glutathione (GSH), the folding pathway of BPTI proceeds through a nonproductive route via N* (a two disulfide intermediate), or a productive route via N" (and other two disulfide intermediates which are in rapid equilibrium with N"). | Glutathione Disulfide | spleen trypsin inhibitor I | Bos taurus |
| 4 | Interestingly, BPTI folds more efficiently in the presence of 5 mM GSSG and 5 mM GSH than it does under traditional conditions. | Glutathione Disulfide | spleen trypsin inhibitor I | Bos taurus |