Title : Celastrol inhibits production of nitric oxide and proinflammatory cytokines through MAPK signal transduction and NF-kappaB in LPS-stimulated BV-2 microglial cells.

Pub. Date : 2007 Dec 31

PMID : 18160842






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 We report here that the LPS-elicited excessive production of NO, TNF-alpha, and IL-1beta in BV-2 cells was largely inhibited in the presence of celastrol, and the attenuation of inducible iNOS and these cytokines resulted from the reduced expression of mRNAs of iNOS and these cytokines, respectively. celastrol interleukin 1 beta Mus musculus