Title : Antagonism of microRNA-122 in mice by systemically administered LNA-antimiR leads to up-regulation of a large set of predicted target mRNAs in the liver.

Pub. Date : 2008 Mar

PMID : 18158304






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 MicroRNA-122 (miR-122) is an abundant liver-specific miRNA, implicated in fatty acid and cholesterol metabolism as well as hepatitis C viral replication. Cholesterol microRNA 122 Mus musculus
2 Functional antagonism of miR-122 was inferred from a low cholesterol phenotype and de-repression within 24 h of 199 liver mRNAs showing significant enrichment for miR-122 seed matches in their 3" UTRs. Cholesterol microRNA 122 Mus musculus