Title : Midazolam metabolism in cytochrome P450 3A knockout mice can be attributed to up-regulated CYP2C enzymes.

Pub. Date : 2008 Mar

PMID : 18156313






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 We provide evidence that CYP2C enzymes, which were found to be up-regulated in Cyp3a knockout mice, are primarily responsible for this metabolism and that several but not all murine CYP2C enzymes are capable of metabolizing midazolam to its 1"-OH and/or 4-OH derivatives. 4-oh cytochrome P450, family 3, subfamily a, polypeptide 11 Mus musculus