Title : Activation of estrogen receptor signaling by the dioxin-like aryl hydrocarbon receptor agonist, 3,3',4,4',5-pentachlorobiphenyl (PCB126) in salmon in vitro system.

Pub. Date : 2008 Mar 1

PMID : 18155262






2 Functional Relationships(s)
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1 Firstly, salmon primary hepatocytes were exposed to the dioxin-like PCB126 at 1, 10 and 50 nM [corrected] and ER agonist nonylphenol (NP) at 5 and 10 microM, singly or in combination. Dioxins pyruvate carboxylase Homo sapiens
2 Although not conclusive, our findings represent the first study showing the activation of estrogenic responses by a dioxin-like PCB in fish in vitro system and resemble the "ER-hijacking" hypothesis that was recently proposed. Dioxins pyruvate carboxylase Homo sapiens