Title : Activation of growth hormone receptors by growth hormone and growth hormone antagonist dimers: insights into receptor triggering.

Pub. Date : 2008 Apr

PMID : 18096690






2 Functional Relationships(s)
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1 As expected, GH and GH-GH, but not G120R, induced GHR disulfide linkage, as assessed by anti-GHR blotting of cell extracts resolved by SDS-PAGE under nonreducing conditions. Disulfides growth hormone receptor Homo sapiens
2 Notably, G120R-G120R, despite its lack of an intact site 2 in either dimer partner, also promoted GHR disulfide linkage and JAK2 and STAT5 activation, albeit less potently than either GH or GH-GH. Disulfides growth hormone receptor Homo sapiens