Title : Dynamic regulation of neutrophil survival through tyrosine phosphorylation or dephosphorylation of caspase-8.

Pub. Date : 2008 Feb 29

PMID : 18086677






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Phosphorylation of caspase-8 on Tyr-310 facilitates its interaction with the Src-homology domain 2 containing tyrosine phosphatase-1 (SHP-1) and enables SHP-1 to dephosphorylate caspase-8, permitting apoptosis to proceed. Tyrosine protein tyrosine phosphatase non-receptor type 6 Homo sapiens
2 Phosphorylation of caspase-8 on Tyr-310 facilitates its interaction with the Src-homology domain 2 containing tyrosine phosphatase-1 (SHP-1) and enables SHP-1 to dephosphorylate caspase-8, permitting apoptosis to proceed. Tyrosine protein tyrosine phosphatase non-receptor type 6 Homo sapiens