Pub. Date : 2008 Feb 2
PMID : 18083161
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Berberine inhibits RANKL-induced osteoclast formation and survival through suppressing the NF-kappaB and Akt pathways. | Berberine | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | RANKL-induced Akt phosphorylation was strongly inhibited by berberine; however, neither monocyte/macrophage-colony stimulating factor (M-CSF)-induced nor insulin-induced Akt activation was inhibited by the drug. | Berberine | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | These findings indicate that berberine inhibits osteoclast formation and survival through suppression of NF-kappaB and Akt activation and that both pathways in the osteoclast lineage are highly sensitive to berberine treatment. | Berberine | AKT serine/threonine kinase 1 | Homo sapiens |